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Cysteine and methionine metabolism

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
pyruvate + L-2-aminobutanoate <=> L-alanine + 2-oxobutyrate 2.6.1.12 alanine---oxo-acid transaminase
2.6.1.40 (R)-3-amino-2-methylpropionate---pyruvate transaminase
2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.44 alanine---glyoxylate transaminase
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H+ + S-Glutathionyl-L-cysteine + NADPH <=> L-cysteine + glutathione + NADP+ 1.8.1.10 CoA-glutathione reductase
1.8.1.9 thioredoxin-disulfide reductase
1.8.4.2 protein-disulfide reductase (glutathione)
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L-methionine + H2O + O2 <=> 4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2 1.13.12.9 phenylalanine 2-monooxygenase
1.4.3.2 L-amino-acid oxidase
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1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O2 <=> H+ + 3-(methylthio)propanoate + formate + CO 1.13.11.53 acireductone dioxygenase (Ni2+-requiring)
1.13.11.54 acireductone dioxygenase [iron(II)-requiring]
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L-cysteine + 2-oxoglutarate <=> 3-Mercaptopyruvate + L-glutamate 2.6.1.1 aspartate transaminase
2.6.1.3 cysteine transaminase
2.6.1.5 tyrosine transaminase
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O-phospho-L-serine + thiosulfate <=> S-sulfocysteine + phosphate 2.5.1.65 O-phosphoserine sulfhydrylase
2.8.5.1 S-sulfo-L-cysteine synthase (3-phospho-L-serine-dependent)
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L-cysteine <=> D-cysteine 5.1.1.10 amino-acid racemase
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L-homocysteine + 5-methyltetrahydrofolate <=> L-methionine + tetrahydrofolate 2.1.1.13 methionine synthase
2.1.1.14 5-methyltetrahydropteroyltriglutamate---homocysteine S-methyltransferase
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L-homocystine + glutathione <=> GSSG + L-homocysteine 1.8.4.1 glutathione---homocystine transhydrogenase
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5-methyltetrahydropteroyl-gamma-glutamyl-gamma-glutamylglutamate + L-homocysteine <=> tetrahydropteroyl-Glu3 + L-methionine 2.1.1.13 methionine synthase
2.1.1.14 5-methyltetrahydropteroyltriglutamate---homocysteine S-methyltransferase
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S-sulfocysteine + thioredoxin <=> L-cysteine + sulfite + thioredoxin_disulfide not assigned
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S-methyl-5''-thioinosine + phosphate <=> hypoxanthine + S-methyl-5-thio-alpha-D-ribose_1-phosphate 2.4.2.1 purine-nucleoside phosphorylase
2.4.2.28 S-methyl-5'-thioadenosine phosphorylase
2.4.2.44 S-methyl-5'-thioinosine phosphorylase
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L-homoserine + NADP+ <=> L-aspartate_4-semialdehyde + NADPH + H+ 1.1.1.3 homoserine dehydrogenase
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spermidine + S-adenosylmethioninamine <=> H+ + spermine + S-methyl-5''-thioadenosine 2.5.1.104 N1-aminopropylagmatine synthase
2.5.1.16 spermidine synthase
2.5.1.22 spermine synthase
2.5.1.23 sym-norspermidine synthase
2.5.1.79 thermospermine synthase
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S-adenosyl-L-methionine + L-homocysteine <=> L-methionine + S-adenosyl-L-homocysteine + H+ 2.1.1.10 homocysteine S-methyltransferase
2.1.1.13 methionine synthase
2.1.1.14 5-methyltetrahydropteroyltriglutamate---homocysteine S-methyltransferase
2.1.1.280 selenocysteine Se-methyltransferase
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L-homoserine + succinyl-CoA <=> O-succinyl-L-homoserine + CoA 2.3.1.46 homoserine O-succinyltransferase
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O-succinyl-L-homoserine + L-cysteine <=> L-cystathionine + succinate + H+ 2.5.1.48 cystathionine gamma-synthase
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S-adenosyl-L-methionine + acyl-[acyl-carrier_protein] <=> [acyl-carrier_protein] + S-methyl-5''-thioadenosine + an_N-acyl-L-homoserine_lactone + H+ 2.3.1.184 acyl-homoserine-lactone synthase
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S-methyl-5''-thioadenosine + phosphate <=> adenine + S-methyl-5-thio-alpha-D-ribose_1-phosphate 2.4.2.1 purine-nucleoside phosphorylase
2.4.2.28 S-methyl-5'-thioadenosine phosphorylase
3.2.2.9 adenosylhomocysteine nucleosidase
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ATP + 5-methylthioribose <=> H+ + ADP + S-methyl-5-thio-alpha-D-ribose_1-phosphate 2.7.1.100 S-methyl-5-thioribose kinase
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L-cystathionine + H2O <=> L-cysteine + 2-oxobutyrate + NH3 2.5.1.48 cystathionine gamma-synthase
4.4.1.1 cystathionine gamma-lyase
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L-cysteic_acid + H2O <=> sulfite + pyruvate + NH3 + H+ 4.4.1.25 L-cysteate sulfo-lyase
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H+ + S-methyl-5''-thioadenosine + H2O <=> S-methyl-5''-thioinosine + NH3 3.5.4.31 S-methyl-5'-thioadenosine deaminase
3.5.4.4 adenosine deaminase
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L-methionine + H2O <=> methanethiol + 2-oxobutyrate + NH3 4.4.1.11 methionine gamma-lyase
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2-oxo-3-sulfinopropionate + H2O <=> H+ + sulfite + pyruvate 0.0.0.0
3.13.1
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O2 + L-cysteine <=> H+ + L-cysteine_sulfinic_acid 1.13.11.20 cysteine dioxygenase
1.14.99.52 L-cysteinyl-L-histidinylsulfoxide synthase
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3-Mercaptopyruvate + thioredoxin <=> pyruvate + Sulfide + thioredoxin_disulfide 2.8.1.2 3-mercaptopyruvate sulfurtransferase
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S-Glutathionyl-L-cysteine + sulfate <=> S-sulfocysteine + glutathione 1.8.4.3 glutathione---CoA-glutathione transhydrogenase
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S-methyl-5-thio-D-ribulose_1-phosphate <=> 5-(methylthio)-2,3-dioxopentyl_phosphate + H2O 4.2.1.109 methylthioribulose 1-phosphate dehydratase
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L-cysteine + NAD+ <=> H+ + L-cystine + NADH 1.8.1.6 cystine reductase
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O-acetyl-L-homoserine + Sulfide <=> H+ + L-homocysteine + acetate 2.5.1.49 O-acetylhomoserine aminocarboxypropyltransferase
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glycine + gamma-Glu-2-aminobutyrate + ATP <=> ophthalmate + ADP + phosphate + H+ 6.3.2.3 glutathione synthase
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L-cysteine_sulfinic_acid + 2-oxoglutarate <=> 2-oxo-3-sulfinopropionate + L-glutamate 2.6.1
2.6.1.1 aspartate transaminase
2.6.1.3 cysteine transaminase
2.6.1.75 cysteine-conjugate transaminase
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L-serine <=> 2-aminoacrylate + H2O 4.3.1.17 L-serine ammonia-lyase
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O-acetyl-L-homoserine + thiosulfate + thioredoxin + H+ <=> L-homocysteine + sulfite + thioredoxin_disulfide + acetate not assigned
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L-homoserine + NAD+ <=> L-aspartate_4-semialdehyde + NADH + H+ 1.1.1.3 homoserine dehydrogenase
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L-2-aminobutanoate + 2-oxoglutarate <=> L-glutamate + 2-oxobutyrate 2.6.1
2.6.1.2 alanine transaminase
2.6.1.42 branched-chain-amino-acid transaminase
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H2O + D-cysteine <=> NH3 + pyruvate + Sulfide 4.4.1.15 D-cysteine desulfhydrase
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putrescine + S-adenosylmethioninamine <=> H+ + spermidine + S-methyl-5''-thioadenosine 2.5.1.104 N1-aminopropylagmatine synthase
2.5.1.16 spermidine synthase
2.5.1.23 sym-norspermidine synthase
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L-cysteine_sulfinic_acid + NAD+ + H2O <=> 2-oxo-3-sulfinopropionate + NH3 + NADH + H+ 1.4.1
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L-methionine + 2-oxoglutarate <=> 4-methylsulfanyl-2-oxobutanoate + L-glutamate 2.6.1.1 aspartate transaminase
2.6.1.2 alanine transaminase
2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.5 tyrosine transaminase
2.6.1.57 aromatic-amino-acid transaminase
2.6.1.6 leucine transaminase
2.6.1.7 kynurenine---oxoglutarate transaminase
2.6.1.73 methionine---glyoxylate transaminase
2.6.1.88 methionine transaminase
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L-cysteine + 2-oxoglutarate <=> 3-Mercaptopyruvate + L-glutamate 2.6.1.1 aspartate transaminase
2.6.1.3 cysteine transaminase
2.6.1.5 tyrosine transaminase
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L-serine + ADP <=> O-phospho-L-serine + AMP + H+ 2.7.1.226 L-serine kinase (ADP)
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Sulfide + L-aspartate_4-semialdehyde + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> L-homocysteine + H2O + oxidized_ferredoxin 2.8.1.16 L-aspartate semialdehyde sulfurtransferase
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S-adenosyl-L-methionine <=> S-adenosyl-L-homocysteine 2.1.1
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5-(methylthio)-2,3-dioxopentyl_phosphate <=> H+ + 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl_phosphate 3.1.3.77 acireductone synthase
4.1.1.39 ribulose-bisphosphate carboxylase
4.2.1.11 phosphopyruvate hydratase
5.3.2.5 2,3-diketo-5-methylthiopentyl-1-phosphate enolase
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L-tryptophan + 4-methylsulfanyl-2-oxobutanoate <=> 3-Indole-2-oxopropanoate + L-methionine 2.6.1
2.6.1.27 tryptophan transaminase
2.6.1.57 aromatic-amino-acid transaminase
2.6.1.88 methionine transaminase
2.6.1.99 L-tryptophan---pyruvate aminotransferase
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L-cystine + glutathione <=> GSSG + L-cysteine 1.8.1.6 cystine reductase
1.8.4.4 glutathione---cystine transhydrogenase
1.8.4.9 adenylyl-sulfate reductase (glutathione)
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S-methyl-5''-thioadenosine + H2O <=> 5-methylthioribose + adenine 3.2.2.16 methylthioadenosine nucleosidase
3.2.2.9 adenosylhomocysteine nucleosidase
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(S)-3-sulfolactate + NAD+ <=> 3-sulfopyruvate + NADH + H+ 1.1.1.272 D-2-hydroxyacid dehydrogenase (NADP+)
1.1.1.310 (S)-sulfolactate dehydrogenase
1.1.1.337 L-2-hydroxycarboxylate dehydrogenase (NAD+)
1.1.1.375 L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]
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(2R)-3-sulfolactate + NADP+ <=> 3-sulfopyruvate + NADPH + H+ 1.1.1.338 (2R)-3-sulfolactate dehydrogenase (NADP+)
1.1.1.375 L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]
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L-cysteine_sulfinic_acid <=> L-alanine + SO2 4.1.1.12 aspartate 4-decarboxylase
4.4.1.1 cystathionine gamma-lyase
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S-adenosyl-L-methionine + H+ <=> CO2 + S-adenosylmethioninamine 4.1.1.19 arginine decarboxylase
4.1.1.50 adenosylmethionine decarboxylase
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O-acetyl-L-serine + thiosulfate <=> H+ + S-sulfocysteine + acetate 2.5.1.144 S-sulfo-L-cysteine synthase (O-acetyl-L-serine-dependent)
2.5.1.47 cysteine synthase
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S-adenosyl-L-homocysteine + H2O <=> S-ribosylhomocysteine + adenine 3.2.2.16 methylthioadenosine nucleosidase
3.2.2.30 aminodeoxyfutalosine nucleosidase
3.2.2.9 adenosylhomocysteine nucleosidase
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2-aminoacrylate + 3''-Phosphoadenylyl_sulfate <=> L-cysteic_acid + Adenosine_3'',5''-bisphosphate not assigned
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S-ribosylhomocysteine <=> L-homocysteine + (S)-4,5-dihydroxypentan-2,3-dione 4.4.1.21 S-ribosylhomocysteine lyase
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O-acetyl-L-homoserine + L-cysteine <=> L-cystathionine + acetate 2.5.1.48 cystathionine gamma-synthase
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O-acetyl-L-serine + L-homocysteine <=> L-cystathionine + acetate + H+ 2.5.1.134 cystathionine beta-synthase (O-acetyl-L-serine)
2.5.1.47 cysteine synthase
4.2.1.22 cystathionine beta-synthase
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Aminoacyl-L-methionine + H2O <=> L-methionine 3.4.13.12 Met-Xaa dipeptidase
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S-adenosyl-L-methionine <=> H+ + S-methyl-5''-thioadenosine + 1-aminocyclopropane-1-carboxylate 4.4.1.14 1-aminocyclopropane-1-carboxylate synthase
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ATP + L-methionine + H2O <=> S-adenosyl-L-methionine + phosphate + diphosphate 2.5.1.6 methionine adenosyltransferase
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L-serine + L-homocysteine <=> L-cystathionine + H2O 2.5.1.47 cysteine synthase
4.2.1.22 cystathionine beta-synthase
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H2O + N-formyl-L-methionine <=> L-methionine + formate 3.5.1.14 N-acyl-aliphatic-L-amino acid amidohydrolase
3.5.1.16 acetylornithine deacetylase
3.5.1.31 formylmethionine deformylase
3.5.1.87 N-carbamoyl-L-amino-acid hydrolase
3.5.1.88 peptide deformylase
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L-glutamine + 4-methylsulfanyl-2-oxobutanoate <=> 2-Oxoglutaramate + L-methionine 2.6.1.117 L-glutamine---4-(methylsulfanyl)-2-oxobutanoate aminotransferase
2.6.1.15 glutamine---pyruvate transaminase
2.6.1.64 glutamine---phenylpyruvate transaminase
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O-acetyl-L-serine + Sulfide <=> L-cysteine + acetate + H+ 2.5.1.47 cysteine synthase
2.5.1.49 O-acetylhomoserine aminocarboxypropyltransferase
2.5.1.65 O-phosphoserine sulfhydrylase
4.2.1.22 cystathionine beta-synthase
4.2.1.50 pyrazolylalanine synthase
4.4.1.9 L-3-cyanoalanine synthase
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L-homoserine + acetyl-CoA <=> O-acetyl-L-homoserine + CoA 2.3.1.31 homoserine O-acetyltransferase
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S-adenosyl-L-homocysteine + H2O <=> L-homocysteine + adenosine 3.3.1.1 adenosylhomocysteinase
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L-glutamate + L-2-aminobutanoate + ATP <=> gamma-Glu-2-aminobutyrate + ADP + phosphate + H+ 6.3.2.2 glutamate---cysteine ligase
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(2R)-3-sulfolactate <=> pyruvate + sulfite + H+ 4.4.1.24 (2R)-sulfolactate sulfo-lyase
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L-aspartate + ATP <=> L-4-aspartyl_phosphate + ADP 2.7.2.4 aspartate kinase
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O-succinyl-L-homoserine + Sulfide <=> H+ + L-homocysteine + succinate 2.5.1
2.5.1.48 cystathionine gamma-synthase
2.5.1.49 O-acetylhomoserine aminocarboxypropyltransferase
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L-cystine + sulfate <=> S-sulfocysteine + L-cysteine 1.8.4.3 glutathione---CoA-glutathione transhydrogenase
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L-cystine + H2O <=> thiocysteine + pyruvate + NH3 4.4.1.1 cystathionine gamma-lyase
4.4.1.13 cysteine-S-conjugate beta-lyase
4.4.1.3 dimethylpropiothetin dethiomethylase
4.4.1.35 L-cystine beta-lyase
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1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O2 <=> H+ + 4-methylsulfanyl-2-oxobutanoate + formate 1.13.11.54 acireductone dioxygenase [iron(II)-requiring]
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L-methionine + thioredoxin_disulfide + H2O <=> methionine_sulfoxide + thioredoxin 1.8.4.13 L-methionine (S)-S-oxide reductase
1.8.4.14 L-methionine (R)-S-oxide reductase
1.8.4.5 methionine-S-oxide reductase
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5-(methylthio)-2,3-dioxopentyl_phosphate + H2O <=> H+ + 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate 3.1.3.77 acireductone synthase
3.1.3.87 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase
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2-hydroxy-5-(methylthio)-3-oxopent-1-enyl_phosphate + H2O <=> 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate 3.1.3.77 acireductone synthase
3.1.3.87 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase
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H+ + sulfite + L-cysteine <=> Sulfide + L-cysteic_acid 4.4.1.10 cysteine lyase
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S-adenosyl-L-methionine + cytosine_(in_DNA) <=> 5-methylcytosine_in_DNA + S-adenosyl-L-homocysteine + H+ 2.1.1.37 DNA (cytosine-5-)-methyltransferase
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S-methyl-5-thio-alpha-D-ribose_1-phosphate <=> S-methyl-5-thio-D-ribulose_1-phosphate 5.3.1.23 S-methyl-5-thioribose-1-phosphate isomerase
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ascorbate + 1-aminocyclopropane-1-carboxylate + O2 <=> H2O + ethylene + dehydroascorbate + cyanide + CO2 1.14.17.4 aminocyclopropanecarboxylate oxidase
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O-phospho-L-serine + Sulfide <=> L-cysteine + phosphate 2.5.1.47 cysteine synthase
2.5.1.65 O-phosphoserine sulfhydrylase
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3-Mercaptolactate + NAD+ <=> 3-Mercaptopyruvate + NADH + H+ 1.1.1.27 L-lactate dehydrogenase
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3-phospho-D-glycerate + NAD+ <=> H+ + 3-phosphohydroxypyruvate + NADH 1.1.1.95 phosphoglycerate dehydrogenase
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L-cysteic_acid + 2-oxoglutarate <=> 3-sulfopyruvate + L-glutamate 2.6.1.1 aspartate transaminase
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L-cysteine + H2O <=> pyruvate + Sulfide + NH3 4.4.1.1 cystathionine gamma-lyase
4.4.1.11 methionine gamma-lyase
4.4.1.13 cysteine-S-conjugate beta-lyase
4.4.1.28 L-cysteine desulfidase
4.4.1.3 dimethylpropiothetin dethiomethylase
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(2R)-3-sulfolactate + NAD+ <=> H+ + 3-sulfopyruvate + NADH 1.1.1.337 L-2-hydroxycarboxylate dehydrogenase (NAD+)
1.1.1.37 malate dehydrogenase
1.1.1.375 L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]
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L-homocysteine + betaine <=> L-methionine + N,N-dimethylglycine 2.1.1.5 betaine---homocysteine S-methyltransferase
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O-phospho-L-serine + 2-oxoglutarate <=> L-glutamate + 3-phosphohydroxypyruvate 2.6.1.52 phosphoserine transaminase
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L-aspartate_4-semialdehyde + phosphate + NADP+ <=> L-4-aspartyl_phosphate + NADPH + H+ 1.2.1.11 aspartate-semialdehyde dehydrogenase
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H2O + 1-aminocyclopropane-1-carboxylate <=> NH3 + 2-oxobutyrate 3.5.99.7 1-aminocyclopropane-1-carboxylate deaminase
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L-cystathionine + H2O <=> L-homocysteine + pyruvate + NH3 2.5.1.48 cystathionine gamma-synthase
3.5.1.61 mimosinase
4.2.1.22 cystathionine beta-synthase
4.4.1.1 cystathionine gamma-lyase
4.4.1.13 cysteine-S-conjugate beta-lyase
4.4.1.28 L-cysteine desulfidase
4.4.1.3 dimethylpropiothetin dethiomethylase
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L-serine + acetyl-CoA <=> O-acetyl-L-serine + CoA 2.3.1.30 serine O-acetyltransferase
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O-succinyl-L-homoserine + H2O <=> 2-oxobutyrate + succinate + NH3 + H+ 2.5.1.48 cystathionine gamma-synthase
4.3.1
4.4.1.13 cysteine-S-conjugate beta-lyase
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Visualization of the pathway